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8

CRISPR platform can reduce stem cell differentiation from months to weeks (phys.org)

by PaulHoule 19 hours ago | hide | 0 comments

115

Pfizer ended up passing on my GLP-1 work back in the early '90s (2024) (statnews.com)

by rajlego 3 days ago | hide | 51 comments

27

Show HN: Phantas – A browser-based binaural strobe engine (Web Audio API) (phantas.io)

by AphantaZach 2 days ago | hide | 8 comments

72

Gaussian Splatting 3 Ways (github.com)

by nullandkale 4 days ago | hide | 8 comments

242

Google's year in review: areas with research breakthroughs in 2025 (blog.google)

by Anon84 6 days ago | hide | 168 comments

136

Show HN: AutoLISP interpreter in Rust/WASM – a CAD workflow invented 33 yrs ago (acadlisp.de)

by holg 4 days ago | hide | 44 comments

119

Drawing with zero-width characters (zw.swerdlow.dev)

by benswerd 4 days ago | hide | 31 comments

8

Ship comms: how do they work?–lightning talk by Matt Kulukundis [video] (youtube.com)

by leoc 15 hours ago | hide | 0 comments

8

Ask HN: How do you manage kids' accounts?

by xfax 16 hours ago | hide | 3 comments

69

They made me an offer I couldn't refuse (1997) (jens.mooseyard.com)

by classichasclass 7 days ago | hide | 35 comments

92

Global Memory Shortage Crisis: Market Analysis (idc.com)

by naves 2 days ago | hide | 101 comments

101

Show HN: Lamp Carousel – DIY kinetic sculpture powered by lamp heat (2024) (evan.widloski.com)

by Evidlo 6 days ago | hide | 21 comments

1677

Inside CECOT – 60 Minutes [video] (archive.org)

by lawlessone 8 days ago | hide | 548 comments

6

The Late Arrival of 16-Bit CP/M – By Nemanja Trifunovic (nemanjatrifunovic.substack.com)

by rbanffy 17 hours ago | hide | 0 comments

6

Pharmacologic reversal of advanced Alzheimer's disease in mice (cell.com)

by pfrrp a day ago | hide | 0 comments

208

How Lewis Carroll computed determinants (2023) (johndcook.com)

by tzury 4 days ago | hide | 72 comments

269

LearnixOS (learnix-os.com)

by gtirloni 4 days ago | hide | 107 comments

5

Why most software startups don't need VCs anymore (most) (sderosiaux.substack.com)

by chtefi 15 hours ago | hide | 0 comments

11

Show HN: Matchstick Puzzle Game in the Browser (matchmath.pages.dev)

by prettyblocks a day ago | hide | 2 comments

32

An experiment in separating identity, memory, and tools (rcrdbl.com)

by promptfluid 4 days ago | hide | 25 comments

1951

Tell HN: Merry Christmas

by basilikum 6 days ago | hide | 427 comments

12

First Steps with Gleam: Building a Simple Web App (Rest API with PostgreSQL) (blog.andreyfadeev.com)

by andfadeev 2 days ago | hide | 3 comments

77

Loss of moist broadleaf forest in Africa has turned a carbon sink into source (nature.com)

by PaulHoule 2 days ago | hide | 30 comments

487

I sell onions on the Internet (2019) (deepsouthventures.com)

by sogen 5 days ago | hide | 171 comments

6

The Precipice (samirvarma.substack.com)

by paulpauper 18 hours ago | hide | 0 comments

23

Multiscale Aperture Synthesis Imager (nature.com)

by wisty 4 days ago | hide | 1 comments

106

We "solved" C10K years ago yet we keep reinventing it (2003) (kegel.com)

by birdculture 5 days ago | hide | 85 comments

17

Are We Ready to Be Governed by Artificial Intelligence? (merionwest.com)

by leephillips a day ago | hide | 25 comments

6

Hyaluronic Acid in Topical Applications: Hero Molecule in the Cosmetics Industry (mdpi.com)

by PaulHoule 16 hours ago | hide | 0 comments

708

X-ray: a Python library for finding bad redactions in PDF documents (github.com)

by rendx 7 days ago | hide | 123 comments

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